per دانشگاه علوم پزشکی کرمان Journal of Health and Biomedical Informatics 2423-3870 2423-3498 2016-09 3 2 76 84 article Maryam Ebrahimi maryamebrahimi85@gmail.com 1 Roxana Sharifian sharifir@sums.ac.ir 2 Fateme Bahador fatemebahador@gmail.com 3 Fariba Asadi fariba.asadi3@gmail.om 4 Atefe Farmani atfarmani@gmail.com 5 Sara Afrazandeh afrazandehsara@bums.ac.ir 6 ferdows health and paramedical school shraz School of Management M.S.c in Health Information Technology, Lecturer, Health Information Technology Dept., School of Ferdows Paramedical, Birjand University of Medical Science, Birjand, Iran. ferdows health and paramedical school shraz School of Management ferdows health and paramedical school Introduction: Nowadays, the advent of digital medical equipment and using information technology especially in the medical field are accompanied with many advantages and challenges. Therefore, identifying the challenges of modern technologies can significantly help the managers to use technology properly. The aim of this study was to assess the challenges of picture archiving and communication system (PACS) from the users’ perspective. Method: This descriptive analytical study was performed on 53 users of PACS in 2014. Data were collected by a questionnaire that its reliability was calculated by Cronbach’s Alpha (0.78). Data were analyzed and descriptive statistics (frequency distribution table, mean, index of dispersion, and analysis of variance) were obtained using SPSS 18. Results: It was found that 26.4 percent of the users used PACS for 5 years, 58.8 percent used the system for 2-5 years, and 75.5 percent of diagnostic imaging department users also used this system. The results of multivariate analysis of variance (MANOVA) showed that only access to the system is the significant variable, and the average score of challenges in the clinics is higher than those in other departments. Conclusion: The results show that PACS users expressed the opposite opinion about the challenges indicating that users have relative satisfaction from the system and implementation of this system was greatly successful. http://jhbmi.ir/article-1-140-en.pdf Picture Archiving and Communication System (PACS) Challenges Information Technology Shiraz University of Medical Sciences per دانشگاه علوم پزشکی کرمان Journal of Health and Biomedical Informatics 2423-3870 2423-3498 2016-09 3 2 85 91 article Fateme Karimimanesh fateme.karimimanesh@gmail.com 1 Mohammad Davarpanah Jazi mdjazi@cc.iut.ac.ir 2 Nooshin mohamadi Fard nmohammadifard@gmail.com. 3 M.Sc. student in Information System Management, Mechanical Engineering Dept., Foolad Institute of Technology, Isfahan, Iran. Introduction: Nowadays, to obtain useful relationship between risk factors in diseases, data mining techniques are used. The aim of this study was to assess the relationship between nutritional indices and obesity and components of metabolic syndrome using data mining approach. Methods: In this correlational survey, 1019 adolescents (aged 11-18 years) were included and nutritional data were collected using a Food Frequency Questionnaire (FFQ). Dietary Diversity Score (DDS) and Healthy Eating Index (HEI-2010) were calculated. According to the values of metabolic syndrome components, a risk score was determined for each individual. Relationship between the variables was analyzed using linear regression. Results: There was no significant relationship between DDS and components of metabolic syndrome and obesity. However, there was a significant but weak positive relationship between HEI and high waist (B=0.093, P=0.01165), body mass index (BMI) (B=0.309, P=0.022) and waist-to-height ratio (B=0.0006, P=0.005). Conclusion: There was no relationship between DDS and risk of metabolic syndrome and obesity but there was a significant positive relationship between HEI and some components of metabolic syndrome and obesity. It seems that the relationship between nutritional indices in HEI and obesity indices should be assessed in HEI. http://jhbmi.ir/article-1-142-en.pdf DDS HEI Metabolic Syndrome Data Mining Regression per دانشگاه علوم پزشکی کرمان Journal of Health and Biomedical Informatics 2423-3870 2423-3498 2016-09 3 2 92 99 article Yosef Mehdipour saeidebrahimi9@gmail.com 1 Saeid Ebrahimi saeidebrahimi9@gmail.com 2 Jahanpour Alipour saeidebrahimi9@gmail.com 3 Afsaneh Karimi saeidebrahimi9@gmail.com 4 Fatemeh Tabatabei saeidebrahimi9@gmail.com 5 M.Sc. in Health Information Technology, Lecturer, Health Information Technology Dept., Zahedan University of Medical Sciences, Zahedan, Iran. Introduction: Using Electronic healthcare to improve the quality and effectiveness of the health care services is necessary considering the healthcare infrastructure in Iran. The aim of this study was to investigate the determinants of physicians' technology acceptance for e-health in healthcare setting. Methods: This cross-sectional descriptive-analytical study was performed on all physicians working at teaching hospitals. Finally, 140 physicians participated in this study. In order to collect data and test the research hypothesis, a researcher-made questionnaire was used based on the variations of the TAM and UTAUT models. The reliability of questionnaire was confirmed (r=0.8). Data were analyzed using SPSS 22 and SmartPLS 3.2. Results: The average score of perceived efficiency, behavioral intention, importance of information security, intensity of IT use, perceived ease of use, electronic healthcare knowledge, importance of standardization and familiarity process was higher than 3 indicating that the level of variables was intermediate. The structures of the models analyzed in this study had positive effect on the use of electronic healthcare services by the physicians. Conclusion: Based on the findings, the health-care administrators and politicians are recommended to use technology acceptance theories in order to determine the determinants of physicians' technology acceptance and use for e-health and to take steps in improving the healthcare services quality and avoid waste of resources. http://jhbmi.ir/article-1-155-en.pdf Electronic health care services Modern technologies Health per دانشگاه علوم پزشکی کرمان Journal of Health and Biomedical Informatics 2423-3870 2423-3498 2016-09 3 2 100 117 article Saeideh Jafarinezhad jafarinezhad.s707@yahoo.com 1 Mahmood Dehghani Ashkezari 2 Ali Jebali alijebal2011@gmail.com 3 Ph.D. in Medical Nanotechnology Assistant Professor, Medical Biotechnology Research Center, Islamic Azad University-Ashkezar Branch, Ashkezar, Yazd, Iran. Introduction: The aim of this study was to evaluate the performance of three nanomotors on 15 transmembrane amyloid-beta precursor proteins by molecular dynamics simulation. Method: In this study, 15 transmembrane APP (14 mutant forms and one normal) were obtained from National Center for Biotechnology Information (NCBI) and separately modeled in Designer Ascalaph. The synthesized peptides with three-dimensional stable structures were selected to be simulated and then were placed near synthesized nanomotors, hypericin, and retinol using HyperChem. At end of simulation, different parameters such as free energy, intermolecular energy, potential energy, and root mean square displacement (RMSD) were separately obtained for each APP. Finally, the ratio of changes was calculated for each parameter. Results: The results showed that each nanomotor had different performance on different peptides. Hypericin on peptide 5, retinol on peptide 10, and nanomotors partly on peptide 4 had a great performance. But because each nanomotor influences only special mutant peptide and Alzheimer's disease is caused by different mutations, only one type of nanomotors cannot be used to treat Alzheimer's disease. Conclusion: According to the investigations performed on the treatment of Alzheimer’s disease, it can be concluded that retinol with three-dimensional structure and dynamic parameters has great performance on transmembrane mutant peptide; therefore, it can be considered as a useful treatment strategy. http://jhbmi.ir/article-1-141-en.pdf Amyloid Precursor Protein Alzheimer's disease Simulation Nanomotor per دانشگاه علوم پزشکی کرمان Journal of Health and Biomedical Informatics 2423-3870 2423-3498 2016-09 3 2 118 131 article Manevey Naeimi maneveynaeimi@gmail.com 1 Aptin Rahnavard rahnavard_aptin@yahoo.com 2 Ph.D in Pharmaceutic Plants, Assistance Professor Environment Engineering Dept., Pharmaceutic Plants & Environment Source, Islamic Azad University, Tonekabon Branch, Tonekabon, Iran Introduction: Telomere is the physical terminal of linear chromosomes composed of a non-coding sequence that protects the ends of chromosomes. Therefore, evolutionary process of telomerase, as the synthase enzyme of telomere, and its structure in various species should be discussed. The aim of this study was to collect the sequences of telomerase gene family and compare them in order to find motifs protected by this gene family and investigate the proximity of human TERT with other species using bioinformatics and computational methods. This study was performed on the 3 levels of protein, mRNA, and DNA. As the sequences of organisms have been increased, combining plants’ and animals’ data is a challenge. Also, more information about the structure of telomerase can help to find new ways to inhibit this enzyme in cancer. Method: In this in silico study, species had at least 35% evolution similarity were selected from plants and vertebrates. Sequences were aligned using ClastalW program. Organisms’ evolutionary tree was drawn using MEGA5 software and protein motifs were detected using ScanProsite software. Results: Proximity of human TERT with other spices was observed in C-terminal region. Amino acid parts preserved were detected and the reverse transcriptase domain was introduced as conserved functional motifs of all species at protein level. Conclusion: Any removal or disturbance in RT-POL domain lead to enzyme deficiencies in all species. Also, the N-terminal region of TERT because of its high preservation in mammals, was introduced as an attractive target for inhibition of telomerase in breast cancer. http://jhbmi.ir/article-1-154-en.pdf Bioinformatics Phylogenetics Telomerase Cancer per دانشگاه علوم پزشکی کرمان Journal of Health and Biomedical Informatics 2423-3870 2423-3498 2016-09 3 2 132 144 article Somaieh Borjalilu sborjalilu@gmail.com 1 Mohammd ali Mazaheri m_mazaheri@sbu.ac.ir 2 Alireza Talebpor Talebpor@sbu.ac.ir 3 Post Doctoral Psychology Fellow, Education and Psychology Dept., Shahid Beheshti University, Tehran, Iran shahid beheshti university shahid beheshti university Introduction: New technologies have developed health service delivery. Development of smartphone and mobile applications (apps) all around the world has increased the opportunity to access the mental health services. The aim of the study was to introduce the mental health apps based on the evidence. Method: This is a review article. A comprehensive literature search was performed in online databases including SID, Iran Medex, Magiran, PubMed, Psycinfo, Google Scholar, Science Direct, and Scopus. Results: In this study, 12 of 6423 abstracts identified through the research were founded by inclusion criteria. The present Apps provided services in the field of psycho-education, assessment, intervention and social support in the mental health and mental disorder. The results showed the efficacy of mental health Apps in improving health components and behavior change. Conclusion: Mental health Apps have improved the accessibility to mental health services and psychological well- being. Therefore, more attention should be paid to design and development of mental health Apps. For this purposes, ethical considerations and information security are important factors that should be considered when designing and using mental health apps. http://jhbmi.ir/article-1-149-en.pdf E-health Smartphone Mobile Application Mental Health per دانشگاه علوم پزشکی کرمان Journal of Health and Biomedical Informatics 2423-3870 2423-3498 2016-09 3 2 145 154 article Fatemeh Jahanimoghadam fatemehjahani4@gmail.com 1 MahboobehA Abdolalizadeh mahabd55@gmail.com 2 Speciality in Children's Dentistry, Assistant Professor, Oral and Dental Diseases Research Center, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran M.Sc. of Physiotherapy, Physiotherapist, University of Applied Science and Technology, Welfare and Social Security Center in Kerman Province, Kerman, Iran Introduction: With the advent of technology, use of computer has become an essential part of human life. The most important human achievement in recent years is the invention of computer. The main problems caused by computer use are musculoskeletal disorders. However, information about the health problems caused by working with computers and prevention strategies is insufficient. Therefore, the aim of this study was to provide ergonomic principles for working with computers in order to reduce and prevent musculoskeletal disorders, facilitate the Interactions between human and equipment to improve the health and safety of computer users. Method: The keywords of computer, ergonomics, and musculoskeletal disorders were searched in four databases (Pubmed, Google, Scopus, and Medline) during 1994 to 2016, and 70 reviews were found out, among which 42 reviews were selected based on their quality and reliability and scientifically analyzed. Results: It was found that further information, education, and studies are required for preventing chronic pain and musculoskeletal disorders. Furthermore, ergonomic reforms of the equipment and workstation are very essential. Conclusion: In this study, the simple and essential health strategies and ergonomic principles for working with computers, appropriate computer workstation ergonomics, and the need for training and giving information to computer users were described. http://jhbmi.ir/article-1-130-en.pdf Computer Ergonomics Musculoskeletal Disorders per دانشگاه علوم پزشکی کرمان Journal of Health and Biomedical Informatics 2423-3870 2423-3498 2016-09 3 2 155 165 article Hamed Moghaddasi h.moghadasi@sbmu.ac.ir 1 Hamed Mehdizadeh h.mehdizadeh@sbmu.ac.ir 2 SBMU Ph.D. Student in Medical Informatics, Management and Health Information Technology Dept., School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran Introduction: Recent advances in mobile technology combined with medical specialties, have introduced a new option called mobile health that provides new opportunities to improve patients’ health. Mobile health has changed the traditional delivery of healthcare services and also previous assumptions of concepts such as service providers, patients, health care services and lifestyle. The aim of this study was to introduce mobile health concept and application of this technology in management and treatment of skin lesions. Methods: This is a comprehensive review aimed to introduce mobile health application in providing skin care and diagnostic services and clinical outcomes of this method. In this review article, articles on the telemedicine, mobile health, and teledermatology were searched using online databases such as Pubmed, Scopus, Google scholar, Web of Science, and Ebsco. Results: Studies in this area show that use of mobile health in dermatology is superior to the conventional method of teledermatology and this method can be used for diagnosis, treatment, screening, triage, and also management of patients with chronic conditions in their home. Conclusion: Mobile health can be potentially used as a cost effective and available method for providing professional skincare services especially in the economically or geographically-disadvantaged area, thereby, the gap of access to professional services will be filled. http://jhbmi.ir/article-1-137-en.pdf Telemedicine Telehealth Mobile Health Dermatology