Journal of Health and Biomedical Informatics

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Babaei M, Karim H, Rostam Niakan S. Designing a Drug Delivery System for Regulation of Blood Pressure Using Fuzzy Controller. jhbmi 2017; 4 (2) :132-141
URL: http://jhbmi.ir/article-1-206-en.html

Introduction: According to the importance of hypertension, the control and stabilization of blood pressure level is very important. The purpose of this study was to design a system for controlling and regulating arterial blood pressure by using sodium nitroprusside through a fuzzy controller.
Methods: This is an applied study done through cross-sectional method. At first, related studies in the field of designing mathematical models for regulation of blood pressure were investigated. Then, by surveying the results of these studies, the best model was selected and necessary changes were made. In the final phase, the fuzzy controller was designed for blood pressure regulation. All processes of designing and implementation of Fuzzy system were performed in 2010 version of MatLab software.
Results: In the first phase, the fuzzy controller caused rapid and sudden changes in output. Therefore, by modifying the controller to improve the system, the system was able to control the blood pressure after about 3 minutes and returned it to the normal level. But, again, the output of the controller had quick changes. So, by applying a filtered controller, high frequencies were controlled and blood pressure remained constant within about 1 minute.
Conclusion: By using fuzzy control and valid mathematical models,   blood pressure can be controlled and stabilized. Classical methods in dealing with biological systems are highly dependent on model parameters. But, fuzzy control, in facing uncertainty, provides an acceptable response with an acceptable speed.