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:: Volume 4, Issue 3 (Fall 2017) ::
2017, 4(3): 222-231 Back to browse issues page
A Study on the Effect of Seven Different Compounds of Cannabis Extract on the Accumulation of Amyloid Peptide in Alzheimer's Disease through Molecular Simulations
Faezeh Jalalian , Ali Jebali
assotiate Ph.D of Medical Nanotechnology, Assistant Professor, Laboratory Science Dept., School of Paramedicine, Shahid Sadoughi University of Medical Science, Yazd, Iran
Abstract:   (886 Views)
Introduction: Alzheimer's disease is a progressive cerebrovascular disease with irreversible damage, which gradually degrades the mental abilities of the patient. In this study, amyloid peptide was exposed to seven different compounds in the canaboid extract and then, the structure and thermodynamic parameters were evaluated.
Methods: In this study, the three-dimensional structure of beta-amyloid peptide in patients with Alzheimer's disease was prepared from the rcsb database. The main components of canaboid extract were obtained from CHEBI database too. Then, amyloid peptide was subjected to each of the canaboid extract molecules in the molecular dynamics simulation software, and its structural and thermodynamic characteristics were evaluated over 3000 picoseconds.
Results: Comparison of seven different compounds of cannabis extract showed that all cannabis extract compounds were able to change the structure of amyloid peptide. Each compound was able to change the effective surface and volume, and the level of lipophilicty of amyloid peptides.
Conclusion: The ability of these compounds to change the volume and surface is effective in preventing amyloid peptide accumulation. The findings of this study should be investigated in a laboratory scale and then on the human body to detect the efficacy of canaboid extract components exactly.
 
Keywords: Amyloid peptide, Alzheimer's disease, Cannabis extract, Simulation, Molecular dynamics
Full-Text [PDF 1057 kb]   (223 Downloads)    
Type of Study: Original Article | Subject: Bioinformatics
Received: 2017/11/10 | Accepted: 2017/12/19
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Jalalian F, Jebali A. A Study on the Effect of Seven Different Compounds of Cannabis Extract on the Accumulation of Amyloid Peptide in Alzheimer's Disease through Molecular Simulations. Journal of Health and Biomedical Informatics. 2017; 4 (3) :222-231
URL: http://jhbmi.ir/article-1-253-en.html


Volume 4, Issue 3 (Fall 2017) Back to browse issues page
مجله انفورماتیک سلامت و زیست پزشکی Journal of Health and Biomedical Informatics
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