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:: Volume 5, Issue 1 (Spring 2018) ::
2018, 5(1): 56-69 Back to browse issues page
A Review of Prediction Methods of Interaction Sites of Antibody-Protein Complexes Based on Artificial Intelligence
Marzieh Abdi , Mahdi Saadatmand-Tarzjan , Mohammad Taherzadeh Sani , Alireza Haghparast
Ph.D in Bioelectronc, Assistant Professor, Medical Imaging Lab, Department of Electrical Engineering, Ferdowsi University of Mashhad, Mashhad, Iran
Abstract:   (626 Views)
Introduction: Cancer is one of the most important health issues in the current and next centuries. Understanding the mechanism of interaction between antibody-protein residues is essential for designing targeted anticancer drugs based on monoclonal antibodies. Prediction of the effective structure is the first step for production of monoclonal antibodies.
Methods: This paper is a systematic review of the state-of-the-art researches on prediction of interaction sites and specification of antibody structures. Artificial neural networks or web servers are frequently used for evaluation of interaction sites while some researchers have employed evolutionary algorithms for prediction of the effective structure of antibodies. Accordingly, 14 methods based on the protein spatial structure, 28 researches based on the molecular amino-acide sequence (without usage of the spatial structure), and 18 antigen/antibody structure prediction techniques were reviewed.
Results: We demonstrated that the accuracy of structure-based methods can be increased up to 80% while the acuracy of sequence-based methods was rarely better than 75%. Since the spatial structure of many antibodies is unknown, some researchers raised the accuracy (even to 96%) by only antibody sequences able to interact with some similar antigens in training neural networks. Therefore, we suggest this approach for structure prediction of monoclonal antibodies because of its adequate high accuracy.
Conclusion: In this paper, after reviewing available methods for prediction of antibody-protein interaction sites, some suggestions were made for effective prediction of structure of monoclonal antibodies.
Keywords: Immunology, Monoclonal Antibodies, Antibody-Protein Complexes, Artificial Intelligence, Neural Networks
Full-Text [PDF 1115 kb]   (196 Downloads)    
Type of Study: Narrative review articles | Subject: Artificial Intelligence in Healthcare
Received: 2017/09/21 | Accepted: 2018/03/1
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Abdi M, Saadatmand-Tarzjan M, Taherzadeh Sani M, Haghparast A. A Review of Prediction Methods of Interaction Sites of Antibody-Protein Complexes Based on Artificial Intelligence . Journal of Health and Biomedical Informatics. 2018; 5 (1) :56-69
URL: http://jhbmi.ir/article-1-230-en.html

Volume 5, Issue 1 (Spring 2018) Back to browse issues page
مجله انفورماتیک سلامت و زیست پزشکی Journal of Health and Biomedical Informatics
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